Stergios Katsiougiannis, PhD
Assistant Project Scientist
UCLA School of Dentistry
Center for Oral, Head & Neck Oncology Research
Los Angeles, CA
System Analysis of Mouse Models for Sjögren’s Syndrome Pathogenesis
The Lay Abstract is for publicity purposes and should use simple language summarizing the proposed research and its significance.
Primary Sjögren’s syndrome (pSS) is an autoimmune disease affecting 4 million patients in the U.S., 90% of whom are women. This work promises to define molecular targets for initiation and pathogenesis of pSS, which can be tested in predictive mouse models of the disease. The results obtained in mouse models of pSS could lead to novel treatment approaches for the human disease that are based on animal model building.
The Scientific Abstract is written for SSF reviewers and a professional audience.
Primary Sjögren’s syndrome (pSS) is a chronic, autoimmune disease affecting 4 million patients in the U.S. Previous studies utilizing human and mouse models have highlighted several components of the immune systems as well as nonimmunologic factors. However, the intersections between humans and mouse models in terms of pathways and key targets remain elusive. The scientific goal of this proposal is to address the crucial question, “can a mouse model predict the outcome of a clinical intervention for pSS?” Therefore, our goal is to use a systems biology approach to develop models for the initiation, pathogenesis and resolution of pSS. The data for the different stages of the disease will be analyzed by Weighted-Gene Co-Expression Network Analysis (WGCNA). The identified molecular pathways and targets will then be validated on mouse models of pSS development and resolution to generate a validated pSS model based on human disease modeling and mouse model validation.